APC Rat Anti-Mouse CD8α Antibody (S-R540)

產(chǎn)品型號：S0B5086

更新時間：2025-10-08

廠商性質(zhì)：生產(chǎn)廠家

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ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對抗體病理/IHC抗體

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產(chǎn)品介紹

CD8α is a crucial immune glycoprotein that serves as a co-receptor for MHC class I peptide complexes, facilitating the connection between T cells and antigens presented by antigen-presenting cells （APCs）. It interacts with the T-cell receptor （TCR） and MHC class I molecules, recruits LCK kinase, and initiates multiple signaling pathways. CD8α can exist as either an α/β heterodimer or an α/α homodimer, with the αα homodimer being particularly abundant in intraepithelial lymphocytes （IELs） that protect mucosal surfaces. It is expressed on cytotoxic T cells （CTLs） and natural killer （NK） cells, playing a key role in cell-mediated immunity and the regulation of immune responses. Additionally, CD8α is involved in T cell activation and differentiation, and it is a biomarker for various diseases, including COVID-19 and certain cancers.

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