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產(chǎn)品中心抗體/抗原抗體試劑盒S0I0004CD138 IHCstart Kit
產(chǎn)品型號：S0I0004
更新時間：2025-10-11
廠商性質(zhì)：生產(chǎn)廠家
訪問量：440
服務熱線15855403091
產(chǎn)品分類
Syndecan-1 （CD138） is mostly restricted to epithelia, and bears heparan sulfate chains that are capable of interacting with a large array of polypeptides, including extracellular matrix components and potent mediators of proliferation, adhesion and migration. For this reason, it has been studied extensively with respect to carcinomas and tumor progression. Frequently, but not always, syndecan-1 levels decrease as tumor grade, stage and invasiveness and dedifferentiation increase. However, in some tumors, levels of syndecan-1 increase, but the characterization of its distribution is relevant. There can be loss of membrane staining, but acquisition of cytoplasmic and/or nuclear staining that is abnormal. Moreover, the appearance of syndecan-1 in the tumor stroma, either associated with its cellular component or the collagenous matrix, is nearly always a sign of poor prognosis [PMID: 33921767].
The reagent can complete 50 slides for IHC experiment and the primary antibody is excessive.
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