CD8α Mouse mAb (Alexa Fluor? 488 Conjugate) (SDT-1036-34)

產(chǎn)品型號(hào)：S0B1835

更新時(shí)間：2025-08-10

廠商性質(zhì)：生產(chǎn)廠家

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產(chǎn)品介紹

CD8α is a crucial subunit of the CD8 co-receptor complex found on the surface of cytotoxic T lymphocytes （CTLs） and some natural killer （NK） cells. It is a 32 kDa glycoprotein that can form either an α/β heterodimer or an α/α homodimer with CD8β. CD8α plays a vital role in immune responses by binding to MHC class I molecules on antigen-presenting cells （APCs）, facilitating the recognition and destruction of infected or abnormal cells. This interaction helps activate the T cell receptor （TCR） complex, recruiting the LCK kinase and initiating multiple signaling pathways. Additionally, CD8αα homodimers are found on intraepithelial lymphocytes （IELs）, which protect mucosal surfaces like the intestinal barrier.

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