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S0B2097S-RMab? SATB2 Recombinant Rabbit mAb (SDT-R066)

產(chǎn)品型號(hào):S0B2097
更新時(shí)間:2025-10-09
廠商性質(zhì):生產(chǎn)廠家
訪問量:78
服務(wù)熱線15855403091
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SATB2, a nuclear protein known to bind matrix attachment regions, is a key event in initiating myogenic differentiation. The deletion of myoblast SATB2 in vitro initiates chromatin remodeling and accelerates differentiation, which is dependent on the caspase 7-mediated cleavage of SATB2. A genome-wide analysis indicates that SATB2 binding within chromatin loops and near anchor points influences both loop and sub-TAD domain formation. Consequently, the chromatin changes that occur with the removal of SATB2 lead to the derepression of differentiation-inducing factors while also limiting the expression of genes that inhibit this cell fate change.
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