FITC Mouse Anti-Human CD154 Antibody (S-R579)

產(chǎn)品型號(hào)：S0B5417

更新時(shí)間：2025-10-09

廠商性質(zhì)：生產(chǎn)廠家

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ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標(biāo)簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對(duì)抗體病理/IHC抗體

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產(chǎn)品介紹

CD154, also known as CD40 ligand （CD40L） or gp39, is a type II transmembrane protein belonging to the tumor necrosis factor （TNF） superfamily. It is primarily expressed on activated CD4+ T cells and can also be found on other immune cells such as CD8+ T cells, natural killer cells, platelets, dendritic cells, and endothelial cells. CD154 can form a trimeric structure and is crucial for humoral and cellular immunity. Its interaction with CD40, its classical receptor, is essential for B cell activation, proliferation, isotype switching, and germinal center formation. This interaction also plays a significant role in T cell priming and cell-mediated immune responses. In addition to CD40, CD154 can bind to several integrins, including αIIbβ3, α5β1, and αMβ2, which are involved in various inflammatory and immune processes. Abnormal expression of CD154 has been implicated in several autoimmune diseases, such as systemic lupus erythematosus （SLE）, where it contributes to the overproduction of autoantibodies and inflammation.

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