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產(chǎn)品中心抗體/抗原流式抗體S0B5158PE Mouse Anti-Human CD42b Antibody (S-935-7)
產(chǎn)品型號：S0B5158
更新時間：2025-10-08
廠商性質(zhì)：生產(chǎn)廠家
訪問量：66
服務熱線15855403091
產(chǎn)品分類
CD42b, also known as platelet glycoprotein Ib alpha chain （GPIbα）, is a type I transmembrane glycoprotein with a molecular weight of approximately 145 kDa. It is encoded by the GP1BA gene and primarily expressed on the surface of platelets and megakaryocytes. CD42b forms a complex with other proteins, including CD42c （GPIbβ）, CD42a （GPIX）, and CD42d （GPV）, which is essential for platelet adhesion and aggregation. This complex plays a crucial role in hemostasis by binding to von Willebrand factor （vWF）, facilitating platelet attachment to the subendothelium at sites of vascular injury. Mutations or deficiencies in CD42b are associated with Bernard-Soulier syndrome, a rare bleeding disorder characterized by large platelets and impaired platelet function.
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