Rat Anti-Mouse CD226 Antibody (S-R625)

產(chǎn)品型號：S0B5045

更新時間：2025-10-08

廠商性質(zhì)：生產(chǎn)廠家

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ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對抗體病理/IHC抗體

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產(chǎn)品介紹

CD226, also known as DNAM-1, is a type I transmembrane protein belonging to the immunoglobulin superfamily and is widely expressed on the surface of immune cells, including T cells, natural killer （NK） cells, and B cells. It plays a crucial role in immune regulation by interacting with its ligands, CD155 and CD112. CD226 enhances immune cell adhesion, cytotoxic activity, and cytokine secretion upon activation. It is particularly important in antitumor immunity, where it competes with TIGIT and CD96 for ligand binding, thereby promoting the antitumor activity of immune cells. However, its function can be inhibited by the high-affinity binding of TIGIT in the tumor microenvironment. Additionally, CD226 is involved in modulating the function of regulatory T cells （Tregs）, influencing immune tolerance and autoimmune responses.

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