Vinculin Recombinant Rabbit mAb (S-1635-3)

產(chǎn)品型號：S0B1360

更新時間：2025-10-07

廠商性質(zhì)：生產(chǎn)廠家

訪問量：178

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抗體/抗原

ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對抗體病理/IHC抗體

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產(chǎn)品介紹

Vinculin is a cytoskeletal protein enriched in focal adhesions and adherens junctions, playing a crucial role in linking the actin cytoskeleton to adhesion receptors such as integrins and cadherins. It regulates cell adhesion, migration, and mechanotransduction by binding to actin filaments, talin, paxillin, and other components of the adhesion complex. Vinculin exists in two conformational states—an active open state and an inactive closed state—regulated by interactions with binding partners like talin and phosphatidylinositol 4,5-bisphosphate （PIP2）. This protein also enhances mechanosensing through the E-cadherin complex and influences cell morphology and locomotion. Additionally, vinculin stabilizes focal adhesions and can inhibit cell migration, potentially acting as a tumor suppressor by reducing cell motility.

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